Friday , December 3 2021

Scientists develop a universal cancer test & # 39; 10 minutes Science


Scientists have developed a universal cancer test that can & # 39; identify traces of blood disease & # 39; patient.

The cheap and simple test uses fluid to change color to reveal the presence of & # 39; malignant cells anywhere in the body and provides results in & # 39; less than 10 minutes.

While the text is still developing, is based on a radical new approach to cancer detection that can & # 39; to scrutinize & # 39; routine foot simple procedure for physicians.

"A major advantage of & # 39; this technique is that it is very cheap and extremely simple to do, so it can & # 39; to be adopted in clinical quite easily", said Laura Carrascosa, a researcher at the University & # 39; Queensland.

The test has sensitivity & # 39; about 90%, that means about 90 f & # 39; 100 case & # 39; cancer, b & # 39; 10% false positives. This serves as an initial check for cancer, and doctors follow positive results with & # 39; more focused investigations.

"Our technique can & # 39; be & # 39; screening tool to inform clinicians that a patient can & # 39; have cancer, but require subsequent tests with & # 39; other techniques to identify the type and stage of cancer, "said Carrascosa.

The test was made possible by the discovery team & # 39; Queensland that cancer DNA and normal DNA stick to metal surfaces with & # 39; many different ways. This ippermettahom develop a test to distinguish between cells with & # 39; health and kanċerjali, even tiny traces of DNA to find themselves in the blood.

The cells with & # 39; ensure well-functioning health by designing their DNA with & # 39; molecules called methyl groups. They work like the volume controls, the silencing of & # 39; genes that are not needed and changes & # 39; others are. In cancer cells, this distortion is destroyed so that change only genes that help cancer grow. While the DNA inside normal cells should all stood methyl groups on it, the DNA inside the cancer cells is the most exposed part, b & # 39; groups methyl found only in & # 39; small clusters in & # 39; specific locations.

Writing in the journal Nature Communications, the team described a series of Queensland & # 39; tests confirmed the telltale pattern & # 39; methyl groups in breast cancer, prostate and colorectal cancer and lymphoma. Then showed that the models had a dramatic impact on the chemistry of DNA, and the normal DNA and cancer behave b & # 39; very differently in water. "This is a great discovery that nobody worked before," said Carrascosa.

After a series of & # 39; experiments, scientists hitting the new test for cancer. The suspect DNA is added & # 39; water containing tiny nanoparticles of gold. Although made of gold, the particles turn the water pink. If the DNA of cancer cells is then added, sticking nanoparticles b & # 39; such that the water retains its original color. But if the DNA of cells with & # 39; their health is added, the DNA adhering particles b & # 39; a different way, and turn the blue water. "The test is sensitive enough to detect very low levels of & # 39; cancer DNA in the sample," said Carrascosa.

Led by Matt Trau, a professor of chemistry at the University & # 39; Queensland, researchers carried out the test on 200 human cancer DNA sample and b & # 39; health. "We certainly do not know yet whether it is the holy grail for all diagnostic cancer, but it looks really interesting as incredibly simple universal marker for cancer, and as accessible technology and inexpensive that does not require complicated equipment based on laboratory such DNA Sequencing ", Trau said.

Scientists are now working for clinical trials & # 39; patients with a wider range & # 39; a & # 39; & # 39 types; cancer to test the & # 39; now.

To test the cancer today, doctors should collect tissue biopsy of a suspected tumor & # 39; patient. The procedure is invasive and relies on the patient notes in sum & # 39; blow, or report symptoms to the GP WHOSE recognized as a potential sign of & # 39; cancer. less invasive test that has the potential to detect cancer in the earliest possible & # 39; transform how patients are screened for the disease.

The DNA in cancer cells can & # 39; & # 39 by weakening; mutations that drive growth & # 39; Specific tumor, but these mutations tend to vary according to the type of & # 39; cancer. universal cancer test is not accurate enough to indicate the location or size of & # 39; tumor, but doctors give rapid response to the question: this patient has cancer?

The laboratory tests showed that scientists were able to distinguish normal DNA from cancer DNA by seeking a change in color in the gold gold solution was visible to the naked eye in & # 39; we have a few minutes.

"This test can & # 39; done in conjunction with & # 39; other simple tests, and become a diagnostic tool b & # 39; robust that you & # 39; not just saying that you have cancer, but also kind and stage ", said Carrascosa.

GED Brady, of Cancer Research UK Manchester Institute, said: "This approach represents an exciting step & # 39; the lead in finding the tumor DNA in blood samples and opens the possibility of & # 39 ; test based on the generalized blood to detect cancer. other clinical studies are required to assess the full clinical potential of the method. "

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