Wednesday , July 28 2021

Indian non-obese and lean and prone to type 2 diabetes: study

Indian non-obese and lean and prone to type 2 diabetes: study
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Contrary to popular belief, not only obese people and & # 39; overweight but not obese and lean people may be susceptible to Type 2 diabetes.

A recent study found that while the majority of diabetics in the West also overweight and obese, in India nearly 20 to 30 percent suffer from diabetes are obese and some are even lean.

The incidence of type 2 diabetes has been showing a trend & # 39; up in India and other parts of the world. This basically results from insulin resistance. Obesity and lifestyle of sedentary lifestyle are increasing are considered central factors for insulin resistance and diabetes for consequent. However, the new study envelope the myth that the increase in obesity alone is the main causative factor.

Insulin resistance occurs when cells in the muscles, the body fat and liver begin to resist the signal to the hormone insulin is trying to send off glucose (aka sugar body which is the main source of body fuel) is through blood cells. The insulin resistance leads to diabetes, which in medical terms is known as diabetes mellitus type 2 or T2DM.

Dr. Anoop Misra by researchers "width =" 461 "height =" 308 "srcset =" jpg 461w, 150w, /uploads/2019/01/Dr-Anoop-Misra-with-researchers-300x200.jpg content 300w 'size =' (width & # 39; maximum: 461px) 100vw, 461px
Dr. Anoop Misra with researchers

Researchers mkejlu levels of insulin diabetic 87 (67 men and 20 women) and levels of C-peptide. In fact, beta cells in the pancreas that make insulin and release the C-peptide – a polypeptide consisting of 31 amino acids. Although C-peptide does actually affect blood sugar of a person, the doctor can measure the level to understand how making insulin from the person's body.

What did researchers measure the levels of & # 39; C-peptide levels with & # 39; insulin in diabetics being studied? This is because C-peptide at issue & # 39; more constant rate over all the time compared to the secretion of & # 39; insulin. In addition, levels C-peptide are more stable compared to the level of insulin (the half-life is nearly six times that of insulin) to facilitate the response testing of -ċelluli beta, the study indicated. The results revealed that the people included in the study had, at most, the characteristics of & # 39; the adipożità characterized by high body fat, abdominal fat and fatty liver condition, which may not appear outside.

The study concluded that non-obese (BMI below 25) and even lean (BMI below 19) Indians have a high body fat, excess fat in the liver and skeletal muscle mass and less skeletal muscle. B & # 39; in particular, have ectopic fat in the liver (non-alcoholic fatty liver disease) and pancreas (non-alcoholic pancreatic disease), which can contribute to insulin resistance leading to even diabetes f & # 39; young age.

Along with & # 39; high body fat and visceral fat, the researchers also found high levels of & # 39; insulin and C-peptide in 87 diabetic patients studied them. Such patients benefit from better pharmacotherapy using insulin sensitizers or for weight loss therapy, the study noted

In summary of the outcome of the study, Dr. Anoop Misra, the president & # 39; Fortis C-DOC conducted the study, told India Science Wire: Not overly obese but have not only a high body fat but fat is in critical metabolic organ , liver and pancreas. Once that happens, action of the hormone insulin becomes endangered, and blood sugar begins to rise, "

"The Indian Physicians should encourage patients to lose weight even when they are in the normal category & # 39; the body mass index (BMI) to keep the body's girlfriend on negotiorum the simpler side. It can & # 39; prevent diabetes in & # 39; those m & # 39; għandhomxha, and sugar levels in the blood are best managed at & # 39; patients with diabetes ", he added.

The results of this study were published in the journal Diabetes & Metabolic Syndrome: Research & Reviews. The research team included Shajith Anoop, Anoop Misra, Surya Prakash Bhatt, Seema Gulati, and Harsh Mahajan.

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