Thursday , September 16 2021

NIH-funded study shows images after mild brain injury can predict results



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A new study published in JAMA Neurology suggests that certain features seen on CT scans help predict outcomes after mild traumatic brain injury (TBI). Patterns found on the scans can help guide follow-up treatment as well as improve the recruitment and design of a research study for clinical trials of head injury.

Researchers led by Geoffrey Manley, MD, Ph.D., a professor of neurological surgery at the University of California San Francisco, performed CT scans in 1,935 subjects with mild TBI and followed their results up to 12 months later. the damage.

This research was part of the study of Transforming Research and Clinical Knowledge into a Traumatic Brain Injury (TRACK-TBI), a major research effort funded by the National Institutes of Health to improve understanding. of the short- and long-term effects of a head injury and to identify potential treatments.

The researchers identified three distinct sets of patterns on CT scans, indicating different types of injury after a head injury that were associated with various outcomes. The results suggest that a contusion (bleeding in the brain tissue), subarachnoid hemorrhage (bleeding in the cerebrospinal fluid on the brain), subdural hematoma (bleeding between the brain and the thick covering on the brain), and Intraventricular hemorrhage (bleeding into the fluid filled spaces in the center of the brain) were associated with worse outcomes 12 months after injury. An epidural hematoma, describing bleeding between the skull and the outer brain cover known as the dura, was associated with incomplete recovery at 2 and 3 months, but was not associated with long-term adverse outcomes. longer.

The TRACK-TBI study was designed and executed in collaboration with the European Collaborative NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) of 2594 TBI subjects. Both sets of results showed similar patterns on CT scans and similar associations between CT abnormalities with clinical results.

More research is needed to understand the effects of head injury on brain structure and function, and how different types of injury can lead to various outcomes in the short and long term.

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