Friday , August 12 2022

Acne is genetic? The first global study makes a "quantum leap & # 39; & # 39; & # 39; ahead to find a cure for spots


Hope was given to millions of & # 39; those who suffer from acne as a new study suggests that the condition can & # 39; is genetic.

In the first trial of its kind, researchers analyzed the DNA of & # 39; more than 26 700 people – including thousands against severe acne.

The results showed that there were significant genetic variations between people with the condition and those with & # 39; clear skin.

Gen controlling the hair follicles are believed to play a particularly critical at the beginning of the common condition.

The researchers called the study a "significant jump & # 39; forward and hopes that this would lead to more effective treatments to prevent the permanent scars.

The first study of the world shows that acne can & # 39; is genetic and is related to & # 39; Hair follicles & # 39; weak (stock)

The first study of the world shows that acne can & # 39; is genetic and is related to & # 39; Hair follicles & # 39; weak (stock)

The study was conducted by the National Research Institute on Health Center & # 39; Biomedical Research at Guy & # 39; s and St Thomas & # 39; NHS Foundation Trust in & # 39; London.

Acne is a very common condition in adolescents and young adults, b & # 39; about 80 percent & # 39; those & # 39; between 11 and 30 in the UK are affected, according to statistics of the NHS.

About 85 percent & # 39; 12 to 24 years in the United States suffer to some extent, figures from the American Academy of Dermatology suggest.

X People & # 39; likely to suffer in their teenage, b & # 39; symptoms usually disappear by time they reach their mid-20s. However, it can & # 39; bother when adult.

Consultant dermatologist Professor Jonathan Barker and colleagues analyzed the DNA of & # 39; 26 772 people, of whom 5602 had acne.

The researchers found variants related to acne in & # 39; 15 genetic place, of which 12 have not been previously identified.

They also discovered many genetic variants related skin condition that affects the formation of & # 39; hair follicles.

Impaired function of the hair follicle is intended to encourage the colonization of & # 39; bacteria that cause acne leading to inflammation.

"The application & # 39; these genetic approaches to acne never been done before, and it is a big step & # 39; hereinafter", said Professor Barker.

Professor Barker hopes to understand the role of genetics in acne lead to more effective treatments focus on reducing inflammation and the elimination of bacterial colonization.

"When you have knowledge about the genetic basis of & # 39; condition, you & # 39; develop much more effective treatments", he said. "For people who have acne, it is so important to have more treatments available.

"We need to deal with people before and b & # 39; most effective way, so do not get scars, lasting even after the condition has been and gone." The scars affect up to 20 percent of patients.

Writing in the journal Nature Communications, the authors added, "acne can & # 39; have severe emotional and psychological consequences and has been associated with & # 39; depression, unemployment, suicidal ideation and suicide itself.

"The regimes & # 39; treatment & # 39; often ineffective and poorly tolerated, and there is still a substantial unmet medical need."

The study was a collaboration between the group of Professor Barker and Medical Genomics Group Professor Michael Simpson at King & # 39; s College London.

Professor Simpson added: "A number of & # 39; genetic variants show interesting devices that can be really good targets for new drugs or treatments that really help patients."

The researchers emphasize that there are additional genetic variants related to & # 39; acne that have not been discovered.

It is defined as spots and oily skin can & # 39; is red or & # 39; pain. Although not well understood, it is believed that acne is caused by a combination of & # 39; sebum, inflammation and Propionibacterium acnes bacteria that enter the hair follicles.

Treatment of acne varies according to how severe the condition. The NHS advises that if a person has only a few blackheads, whiteheads or spots, proving without a prescription creams containing benzol peroxide.

The peroxide is an antiseptic fronts to reduce the amount of & # 39; bacteria on the skin, to lower the number of & # 39; blackheads and white.

F & # 39; more severe cases, topical retinoids may be prescribed, however, they can cause birth defects and m & # 39; should be taken during pregnancy. Antibiotics can be combined with & # 39; creams and gels.

The hormonal therapies have proven effective in women, b & # 39; particularly if their acne is related to their hormones. An example is the controversial drug isotretinoin, which reduces the production of sebum and prevents the blocking of follicles.

Isotretinoin harm unborn babies, and women are required to sign a form confirming that they understand the risk and will use contraception, even if they are sexually active.

There were also reports & # 39; people who had extreme aggression or thoughts & # 39; suicide while they were taking isotretinoin. The NHS emphasizes, however, m & # 39; there is no evidence that these changes in mood are the result of medication.

S & # 39; WHAT THE CHEMICAL acne?

The acne ċistiku – the most severe form of the skin condition – occurs when oil and dead skin cells build deep within the hair follicles.

If they become infected, you & # 39; & # 39 cause stains; Similar liqueur.

Spots occur when pores in the skin gets clogged, usually with & # 39; dead skin cells. If the bacteria enter the pores, can & # 39; become red and swollen.

The ċistiku acne occurs when the infection enters the skin depth, and create bumps that are filled with & # 39; stamp.

If burst cyst, can & # 39; spreading infection, and cause more outbreaks.

Those who suffer are generally in żagħżagħhom or early 20s, but can be as small as eight or more than 50 years. Cystic acne is more common in men.

The face, chest, back, arms of & # 39; on and are often affected.

The exact cause of & # 39; the ċistiku acne is not clear but it is believed to involve the androgen hormones.

Androgen increase during puberty and can & # 39; lead to clogged pores.

In women, menstrual cycle, pregnancy, menopausal or polycystic ovarian syndrome can also worsen acne.

The drug & # 39; over-the-counter & # 39; you can & # 39; facilitates very mild acne often have no effect on ċistiċi forms.

Dermatologist can & # 39; prescribe oral antibiotics to control bacteria and lower inflammation.

Creams and gels containing retionoid, form & # 39; vitamin A, can also help to close the pores.

Tablets & # 39; birth control pills can also help women regulate their hormones.

It is important to seek treatment to prevent scarring.

Those suffering with acne should not choose their blemishes as it can & # 39; propel more deep infection and spread it.

They also lead to lifestyle & # 39; good healthy life. Research suggests that diets zokkriċi can worsen acne.

Sufferers also try and relax because stress causes the body to release more hormones.

source: Web MD

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