Wednesday , May 25 2022

Accutane and its effects on the bacteria that cause acne


the acne this corresponds to a skin condition & # 39; high frequency, in which the balance of the skin microbiota changed, and shows itself in & # 39; skin rashes of & # 39; varying intensity.

According to statistical data, 8 out of 10 preadolexxenti suffer from it. the common acne Usually seen between 8 and 12 years, as an initial manifestation of puberty. Gender, is more common in & # 39; & # 39 girls, between 14 and 17 years and children aged 16 to 19 years. It is normal to disappear in & # 39; 25 years, although 12% of women and 3% & # 39; men have acne up to 44 years.

This condition can & # 39;
occur at any age, as shown by women who develop it
in the 30s, 40s, 50s and their most. Even newborns are not exempt
bear it.

Acne affects all ethnic groups equally, and is often related to family history, as if the father had, it is more likely that the child and submit.


The negative impact of acne on self-esteem of children and adults is well known. It can & # 39; lead to the development of & # 39; anxiety, loss of & # 39; confidence, social isolation, school and work absenteeism. The ratings could be affected, along with MOCKERS of & # 39; peers, which may continue to complicate situation & # 39; insulation.

F & # 39; & # 39 cases, severe acne,
can lead to teen depression and suicidal thoughts.

The consequences
physics, in addition to the typical skin rash, the kummidi and discomfort in Malta
skin, including dark spots, which can take months or years
disappear F & # 39; those most serious cases presenting cysts and lumps, can
important permanent scars.

All these effects can be prevented or
attenuated to monitor welfare and in & # 39; during which.

Most widespread drugs: isotretinoin

25% of patients with acne vulgaris are prescribed oral antibiotics to be ingested for a period of more than 6 months, which can cause significant side effects, as is the case the disbijjożi or resistance to antibiotics.

These – anti – acne drugs are directed against Cutibacterium acnes, Propionibacterium acnes also known as, A bacterium associated with & # 39; acne and can & # 39; cause opportunistic infections.

the isotretinoin or 13-cis-retinoic acid is a synthetic retinoid (derived & # 39; vitamin A) – is placed in – market under – IP. t mark Accutane– It is one of the most used drugs for the treatment of & # 39; moderate to severe acne, although it is not known exactly how exercise its mechanism and the consequent improvement & # 39; acne.

But isotretinoin has associated a series of & # 39; possible side effects, including depression and liver damage. It also causes severe birth defects dependent on the dose, when the women would make during the period of pregnancy.

Isotretinoin and its changes mikrobijoma

Group & # 39; researchers – School – Medicine & # 39; Journal of Investigative Dermatology, Where show how isotretinoin change the skin mikrobijoma, findings serve to focus b & # 39; differently treatment & # 39; acne.

The main author of the study, Dr. William H. McCoy, explaining that "There fatty areas of the skin to support the growth of & # 39; some
bacterial communities, and we know that some of them seem to
associated with & # 39; acne

The researchers planned to find out whether treatment with isotretinoin would reduce the amount of bacteria, especially drug Cutibacterium acnes, The main microorganism associated with & # 39; acne.

The study included 17 people with acne treated with isotretinoin. The group & # 39; control consisted of eight people: four suffer from acne and four without, which received no treatment.

The team collected surface samples of skin of each participant four times – at 10 months – which were studied. the mikrobiome (Set & # 39; genes from being part of the body microorganisms) by & # 39; sophisticated laboratory techniques.

As a result of this study, it was found that treatment with isotretinoin effectively reduced the number of C. acnes, McCoy explains how: "The drug appears to make the skin less hospitable to bacteria that cause acne"

The team also found

the bacterial diversity on the skin surface was added, to
Show that – presence of & # 39; other types of & # 39; increased in bacteria – number & # 39; after
b'iżotretinoin treatment, a finding that was not previously related
by improving acne.

These results indicate that isotretinoin alter the physical conditions of leather chemicals, and lead to more pro different bacterial populations, rather than directly modifying the amount of & # 39; bacteria present. It was also observed that this effect continued even after treatment was discontinued and the production of sebum returned to normal, as indicated Makedonka Miterva, associate professor of medicine and primary author of the study "After treatment, the microbial communities changed to a mix of populations that seem more at & # 39; health, and that change persists for months after treatment"

How to improve the "quality" bacterial

Understanding how to improve isotretinoin acne is just the first step, since the team is now focusing on larger study to improve the therapy for acne, in McCoy words "Our study suggests that it can & # 39; a way to provide & # 39; type & # 39; & # 39; fertilizer & # 39; or & # 39; Herbicide & # 39; germ on the skin to help promote growth & # 39; Microbial b & # 39; health"

Finding & # 39; type & # 39; substance to improve the quality of the microbiota (population & # 39; microorganisms) is an excellent way to reduce possible side effects associated with & # 39; the isotretinoin, as well as offering advantages for those who take this medicine and provide freedom of choice in pregnant women with & # 39; severe akkne, as McCoy explains: "Women often end up with acne-treatment during their pregnancy because they simply m & # 39; no good therapies that are completely safe for use during that time"

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