Wednesday , March 22 2023

Mannose, sugar "miraculous" that reduces tumor growth


An investigation conducted in the UK found that a monosaccharideknown as mannose, Present in blueberries, oranges and apples can & # 39; slow growth & # 39; tumors and increase the effects of & # 39; chemotherapy.

Tests were conducted in mice with & # 39; multiple cancers and will be tested in humans but is a step towards understanding how mannose can & # 39; is used to helps in cancer treatment, indicate researchers, indicate Cancer Reseach UK

Tumors use more glucose than normal tissue and b & # 39; health. However, it is very difficult to control the amount of & # 39; glucose in your body just by diet. F & # 39; this study, the researchers found that mannose Can & # 39; interferes with glucose to reduce the amount of & # 39; sugar that cancer cells can use.

Kevin Ryan, the main author of the Cancer Research UK Beatson Institute, said: "Tumors require a lot of glucose to grow, to b & # 39; thus limiting the amount that can be use slows the progression of cancer. The problem is that normal tissues also need glucose, so we can not completely removing it from the body. "

"In our study, we found a dose & # 39; & # 39 mannose you can, set up enough glucose to reduce the growth of tumors in mice, but not as much affected normal tissues." This is an initial investigation, but he hoped to find that perfect balance means that, in future, can & # 39; is mannose to cancer patients to improve chemotherapy without deleting your overall health. "

The first researchers examined how the mice responded with & # 39; cancer of the pancreas, lung or skin when added mannose for drinking water and given as an oral treatment. They found that adding the supplement decreased by & # 39; significantly tumor growth and did not cause obvious side effects.

To test how the mannose also can & # 39; t affect cancer treatment, the mice were treated with & # 39; cisplatin and doxorubicin, two of the drugs & # 39; the most widely used chemotherapy. They found that mannose enhanced the effects of chemotherapy, reduced the tumor growth, reduced the size of tumors and even increased life & # 39; a mouse.

Other types & # 39; cancer have also been investigated, such as leukemia, osteosarcoma, ovarian and bowel. The researchers kkulturaw cancer cells in the laboratory and then ittrattawhom mannose to see if their growth was affected.

Some cells responded well to treatment, while others were not. It was also found that the presence of & # 39; enzyme empty pill mannose cells was a good indicator of & # 39; how effective treatment.

Professor Kevin Ryan added: "The next step is to ninvestiga why the treatment works only in & # 39; certain cells, to determine which patients may benefit most from this approach. We hope to begin clinical trials b & # 39; mannose in people as much as & # 39; possible to determine their true potential as a new cancer therapy "

Mannose sometimes used for short periods to treat urinary tract infections, but its long-term effects have not been investigated. It is important to research further before mannose can & # 39; & # 39 used in; cancer patients.

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