Friday , December 3 2021

Two monkeys live more than six months in pig hearts Science


In 1964, the surgeon James Hardy performed the first heart transplant in history. That operation was also the first in which the heart & # 39; individual & # 39; One species was placed in & # 39; another, because the donor had inadvertently ċimpiż. The man who tried to save his life no longer lives two hours after the intervention. Since then, surgeons and scientists have tried to develop methods to enable the use of & # 39; animal organs in humans, but & # 39; have not yet met technical difficulties. Today, in the magazine nature, Scientists from the University & # 39; Munich explain how they managed to get two Baboons three months to live by & # 39; pig heart in their chest and two to meet before six killed. These results, to multiply b & # 39; three more than the previous record & # 39; 57 day & # 39; survival, approaching the possibility that pigs are converted into & # 39; surface & # 39; hearts of humans who need a transplant.

When a person owns a terminal heart disease, transplantation is the only long term solution and pigs should be an option before failure & # 39; human donors. However, the body & # 39; & # one species working in 39; another is not easy. Firstly, the authors & # 39; this work used GM pigs to their hearts resemble those of baboons and do not suffer from rejection of their immune system. In addition, monkeys are treated to curb their defenses and ensure good reception. These types of & # 39; treatments, which are used by & # 39; commonly transplant, increase the risk of & # 39; dangerous infections, which occurred in & # 39; this experiment.

Another step that can & # 39; explain the success of Bruno coordinated REICHART team, from the University & # 39; Munich, is the system to maintain the integrity of the organ during the process. Instead of keeping the heart cold, ippumpjaw cooled solution with oxygenated blood, nutrients and hormones. In the first part of the experiment, carried out in three phases, scientists observed that pig hearts into baboons grew until they died just over a month after the operation. To avoid the problem, reducing the pressure of the monkey blood, which is higher than that of pigs, until the right level for their new hearts, and pharmacological and hormonal treatments have been applied to prevent development cardiac excessive.

Cristina Costa, a researcher at the Institute & # 39; & # 39 Biomedical Research; Bellvitge (IDIBELL), f & # 39; Barcelona, ​​and specialist in & # 39; this type of & # 39; transplants between species, points out that this "area was a bit stuck due to lack of & # 39; good model & # 39; animals and this study establish new 'to these techniques carried out trials with humans. "It required model & # 39; good to test animal organs are generated in & # 39; these pigs modified with new technologies Genomic editing", he concludes.

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