Wednesday , July 28 2021

How exercise can & # 39; help keep our strong memory

From NYT
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A new study finds hormone release during exercise can & # 39; improve brain health and reduce damage and memory loss occurring in dementia.

The study, published this month in & # 39; Nature Medicine, involved mice, but its findings may help to explain how, in & # 39; molecular level, exercise protects our minds and possibly preserve memory and thinking skills, even in & # 39; people are losing their past.

Considerable scientific evidence already shows that exercise modernize minds and affect the view.

Researchers have shown in rats and mice to chase ramps enhance the creation of new brain cells in the hippocampus, a portion of the brain devoted to formation and memory storage.

The exercise can & # 39; also improve the health and function of SINAPSE between neurons there, and that allows brain cells to communicate better.

In people, the epidemiological research indicates that if you are physically active reduces the risk for Alzheimer's disease and other dementias and can also reduce the progression of the disease.

But still many questions about how much exercise commute the inner working of the brain and whether the effects are a result of changes x & # 39; elsewhere in the body also look good for the brain or if changes actually occur in the brain itself.

Those issues have attracted the attention of international scientists consortium, some neuroscientists, other cell biologists, all of which were focused on prevention, treatment and understanding of Alzheimer's disease.

Those concerns were brought hormone called Iris in the sphere of & # 39; interest.

Iris, first identified in 2012 and named after Iris, the messenger of the gods in Greek mythology, is produced by muscles during exercise.

The hormone exceed several biochemical reactions in the whole body, the majority of which related to the metabolism of & # 39; energy.

Because Alzheimer's disease is believed to involve, in part, changes in the way how the brain cells use energy, the left argued scientists that exercise may help protect the brain by increasing -livelli of Iris there.

But if so, they realized, the iris has existed in the human brain. To see whether there was, they collected tissues from brain banks, using the & # 39; sophisticated testing, Iris found there.

The patterns of gene expression in & # 39; textile ones also suggested that much of this iris was created in his own mind.

The levels of the hormone were high especially in the mind of people who were free of dementia when they died, but hardly observed in the brains of people who died b'Alzheimer.

Those tests, however, although interesting, could not say what role scientists can play the iris in mind. So researchers are now gone for mice, some healthy and others bred to develop a form of rodent Alzheimer's.

They infuħu the brains of animals bred to madness by & # 39; concentrated dose & # 39; Iris. Those mice soon began to perform better on memory tests and showing signs of & # 39; enhanced synaptic strength.

At the same time, they soaked the brains of healthy animals b & # 39; a substance that inhibits the production of the iris and then pumped in & # 39; forms of beta amyloid, a protein that combines to form plaques in the brain of those b'Alzheimer. In fact, given the mouse madness.

And, no irises in their minds, the mice & # 39; & # 39 with time; health quickly showed signs of & # 39; memory and worsening dysfunction in SINAPSE between neurons in their hippocampus.

Scientists also looked at the individual neurons of mice with & # 39; health and found that, when added to the iris cells, the gene expression changed with & # 39; ways that are expected to reduce the damage of beta amyloid.

Finally and perhaps most importantly, scientists had mice with & # 39; health work, swimming for hours almost every day for five weeks.

Before, some of the animals were also treated with a substance that blocks the production of the iris.

In untreated animals, the levels of irisina in fjoraw mind during the exercise and after training, after which the brains of the animals were exposed to beta amyloid, they were combat its effects, better and perform better on memory tests than mice exposed.

But the animals could pose irisina not seen a lot of exercise. After exposure to beta amyloid, they performed some tests of memory just as bad as sedentary animals b & # 39; beta amyloid in the brain.

taken as they are, these experiments suggest that exercise can & # 39; partially protect against dementia by leading to an increase in the amount of & # 39; Iris in mind, says Ottavio Arancio, professor of pathology and cell biology at the University & # 39; Columbia, who led the research along with & # 39; two dozen colleagues from the Federal University & # 39; Rio de Janeiro in Brazil, University & # 39; Queen in Canada and other institutions.

But the experiments, though elaborate and multiprongati, used mice, and therefore can not tell whether the exercise and iris function similarly in humans, or how many and what types & # 39; exercises could be the healthier brain.

The results also do not show whether the exercise and the iris can prevent Alzheimer's, but only seem to mitigate some of the effects of the disease in mice once you start.

Scientists involved in the study hope to soon test a pharmaceutical form of & # 39; Iris as a treatment for dementia in animals and eventually people, especially those who have lost the ability to exercise, Arancio says.

But this time, he says, the overall lesson of the study seems to be that "if you can, go to a walk."

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