Monday , October 25 2021

Large study of Black Men With Prostate Cancer genetics to look Beyond



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Researchers at the Keck School of Medicine of USC are leading a $ 26.5 million effort to moyen-the first Large-scale study of Black Men With Prostate Cancer.

"Not-only are African-American Men Twice as likely to DEVELOP Prostate Cancer, pocket They are more likely to have an aggressive, more lethal form of-the disease, and we do not know why," Christopher Haiman, SCD, professor of preventive medicine at the Keck School of Medicine, said in a press release. "It the a health disparity That Need To BE addressed. Considerable money, time and effort have Gone Into Men in studies of European Ancestry; half the time for a Large-scale effort devoted to Men of African Ancestry. "

The COLLABORATIVE effort – Funded by grants From NCI, The National Institute on Minority Health and Health Disparities, And The Prostate Cancer Foundation – Will INCLUDE Investigator From severals Other Institutions and Entities: Rutgers Cancer Institute of New Jersey, New Jersey State Cancer Registry, New Jersey Department of Health, Public Health Institute, Emory University, Johns Hopkins University, LSU Health New Orleans, Baylor College of Medicine, Moffitt Cancer Center, Barbara Ann Karmanos Cancer Institute / Wayne State University and University of California, San Francisco.

HemOnc Today With Haiman spoke about-the-the rationale for study, how-the Research conducted Will Be, What he and colleagues hope to Learn, and the Potential of their Findings IMPLICATIONS.

Question: Can you Describe Print-the rationale for study?

Answer: The rationale behind the gain to Insight Into Genetic-the aggressive nature of Prostate Cancer – Specifically how Genetic Variant With INTERACT social and Environmental Factors That May contribute to Prostate Cancer. Theres Has Been a longstanding disparity in disease Incidence, as well as aggressive disease and mortality, compared amongs Men of African Ancestry With Other Population. There's the strong-evidence Suggest a Genetic basis for some of-the disparities, based upon some of the-That-the work we HAVE DONE African Ancestry Prostate Cancer Consortium. We are now going Beyond genetics.

Q: How Will the-BE study conducted?

A: We plan to Recruits 10,000 Black Men With Prostate Cancer Recently diagnosed. They Will Be PRIMARILY recruited through Cancer registries in California, Detroit, New Jersey, Georgia, Texas, Louisiana and Florida. The Men Will Be Asked to RESPOND to a survey, a sample Provide a saliva, and grant permission for Prostate Cancer Researchers to access their biopsy or tumor tissue. The samples Will Be Used to identify genetic markers for Prostate Cancer and tumor CHARACTERISTICS, With a special emphasis on aggressive Prostate Cancer.

Q: What the Results for the-timeline?

A: Print the a 5-year study. However, we hope to follow These 5-years to an after prospectively Men Other study endpoints, includingï¼ recurrence and mortality.

Q: What do you hope to Learn and colleagues from The study?

A: We are trying to Understand racial and ethnic disparities and find out how social stress and Genetic Factors Influence to work Together risk for aggressive disease. That we hope-the information we glean From Print study and future studies to identify us Strategies Will Help To Prevent Prostate Cancer and Improve outcomes for thoses With Prostate Cancer.

Q: The theres Anything else you would like to Mention That?

A: Enrolling 10,000 Black Men With Prostate Cancer Will Be a considerable challenge. We Want to encourage Black Men to icon participate, as to the through their participation in Print-only study we That Will Be Able to make progress on understanding the-Factors That are contributing to the disease-the Population Print. Recruitment for study-the Will Begin in early 2019. For more information about and how to study-the icon participate, visit www.respondstudy.org. – by Jennifer Southall

For more information:

Christopher Haiman, SCD, Can Be reached at Keck School of Medicine of USC, 1975 Zonal Ave., Los Angeles, CA 90033; email: [email protected]

disclosure: Financial disclosure reports no relevant Haiman.

Researchers at the Keck School of Medicine of USC are leading a $ 26.5 million effort to moyen-the first Large-scale study of Black Men With Prostate Cancer.

"Not-only are African-American Men Twice as likely to DEVELOP Prostate Cancer, pocket They are more likely to have an aggressive, more lethal form of-the disease, and we do not know why," Christopher Haiman, SCD, professor of preventive medicine at the Keck School of Medicine, said in a press release. "It the a health disparity That Need To BE addressed. Considerable money, time and effort have Gone Into Men in studies of European Ancestry; half the time for a Large-scale effort devoted to Men of African Ancestry. "

The COLLABORATIVE effort – Funded by grants From NCI, The National Institute on Minority Health and Health Disparities, And The Prostate Cancer Foundation – Will INCLUDE Investigator From severals Other Institutions and Entities: Rutgers Cancer Institute of New Jersey, New Jersey State Cancer Registry, New Jersey Department of Health, Public Health Institute, Emory University, Johns Hopkins University, LSU Health New Orleans, Baylor College of Medicine, Moffitt Cancer Center, Barbara Ann Karmanos Cancer Institute / Wayne State University and University of California, San Francisco.

HemOnc Today With Haiman spoke about-the-the rationale for study, how-the Research conducted Will Be, What he and colleagues hope to Learn, and the Potential of their Findings IMPLICATIONS.

Question: Can you Describe Print-the rationale for study?

Answer: The rationale behind the gain to Insight Into Genetic-the aggressive nature of Prostate Cancer – Specifically how Genetic Variant With INTERACT social and Environmental Factors That May contribute to Prostate Cancer. Theres Has Been a longstanding disparity in disease Incidence, as well as aggressive disease and mortality, compared amongs Men of African Ancestry With Other Population. There's the strong-evidence Suggest a Genetic basis for some of-the disparities, based upon some of the-That-the work we HAVE DONE African Ancestry Prostate Cancer Consortium. We are now going Beyond genetics.

Q: How Will the-BE study conducted?

A: We plan to Recruits 10,000 Black Men With Prostate Cancer Recently diagnosed. They Will Be PRIMARILY recruited through Cancer registries in California, Detroit, New Jersey, Georgia, Texas, Louisiana and Florida. The Men Will Be Asked to RESPOND to a survey, a sample Provide a saliva, and grant permission for Prostate Cancer Researchers to access their biopsy or tumor tissue. The samples Will Be Used to identify genetic markers for Prostate Cancer and tumor CHARACTERISTICS, With a special emphasis on aggressive Prostate Cancer.

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Q: What the Results for the-timeline?

A: Print the a 5-year study. However, we hope to follow These 5-years to an after prospectively Men Other study endpoints, includingï¼ recurrence and mortality.

Q: What do you hope to Learn and colleagues from The study?

A: We are trying to Understand racial and ethnic disparities and find out how social stress and Genetic Factors Influence to work Together risk for aggressive disease. That we hope-the information we glean From Print study and future studies to identify us Strategies Will Help To Prevent Prostate Cancer and Improve outcomes for thoses With Prostate Cancer.

Q: The theres Anything else you would like to Mention That?

A: Enrolling 10,000 Black Men With Prostate Cancer Will Be a considerable challenge. We Want to encourage Black Men to icon participate, as to the through their participation in Print-only study we That Will Be Able to make progress on understanding the-Factors That are contributing to the disease-the Population Print. Recruitment for study-the Will Begin in early 2019. For more information about and how to study-the icon participate, visit www.respondstudy.org. – by Jennifer Southall

For more information:

Christopher Haiman, SCD, Can Be reached at Keck School of Medicine of USC, 1975 Zonal Ave., Los Angeles, CA 90033; email: [email protected]

disclosure: Financial disclosure reports no relevant Haiman.

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